PNPLA3 Positive Control for STJ502571 peptide (STJ504761)

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STJ504761-5

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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: PNPLA3 Positive Control for STJ502571 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PNPLA3
Gene ID: 80339
Uniprot ID: PLPL3_HUMAN
Specificity: This is positive control is recommended for use in combination with PNPLA3 antibody STJ502571.
Function Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA. Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides. In vitro may express hydrolytic activity against glycerolipids triacylglycerol, diacylglycerol and monoacylglycerol, with a strong preference for oleic acid as the acyl moiety. However, the triacylglycerol hydrolase activity is controversial and may be very low. Possesses phospholipase A2 activity.
Peptide Name 1-Acylglycerol-3-Phosphate O-Acyltransferase Pnpla3
Acylglycerol Transacylase
Adiponutrin
Adpn
Calcium-Independent Phospholipase A2-Epsilon
Ipla2-Epsilon
Lysophosphatidic Acid Acyltransferase
Patatin-Like Phospholipase Domain-Containing Protein 3
Database Links Reactome: R-HSA-1482883
Cellular Localisation Membrane
Single-Pass Type Ii Membrane Protein
Lipid Droplet
Alternative Peptide Names 1-Acylglycerol-3-Phosphate O-Acyltransferase Pnpla3 protein
Acylglycerol Transacylase protein
Adiponutrin protein
Adpn protein
Calcium-Independent Phospholipase A2-Epsilon protein
Ipla2-Epsilon protein
Lysophosphatidic Acid Acyltransferase protein
Patatin-Like Phospholipase Domain-Containing Protein 3 protein
PNPLA3 protein
ADPN protein
C22orf20 protein

Information sourced from Uniprot.org

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