PLK4 Blocking Peptide for STJ506388 peptide (STJ506396)

SKU:
STJ506396-250

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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: PLK4 Blocking Peptide for STJ506388 is synthetically produced from the 300-350 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PLK4
Gene ID: 10733
Uniprot ID: PLK4_HUMAN
Immunogen Region: 300-350
Specificity: This blocking peptide is recommended for use in combination with PLK4 antibody, STJ506388
Post Translational Modifications Acetylation by KAT2A and KAT2B impairs kinase activity by shifting the kinase to an inactive conformation. Ubiquitinated.leading to its degradation by the proteasome. Tyrosine-phosphorylated by TEC.
Function Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification. Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites.
Peptide Name Serine/Threonine-Protein Kinase Plk4
Polo-Like Kinase 4
Plk-4
Serine/Threonine-Protein Kinase 18
Serine/Threonine-Protein Kinase Sak
Database Links Reactome: R-HSA-2565942
Reactome: R-HSA-380259
Reactome: R-HSA-380270
Reactome: R-HSA-380284
Reactome: R-HSA-380320
Reactome: R-HSA-5620912
Reactome: R-HSA-8854518
Cellular Localisation Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Centriole
Nucleus
Nucleolus
Cleavage Furrow
Component Of The Deuterosome
A Structure That Promotes De Novo Centriole Amplification In Multiciliated Cells That Can Generate More Than 100 Centrioles
Associates With Centrioles Throughout The Cell Cycle
It Is Not Present At Cleavage Furrows
Alternative Peptide Names Serine/Threonine-Protein Kinase Plk4 protein
Polo-Like Kinase 4 protein
Plk-4 protein
Serine/Threonine-Protein Kinase 18 protein
Serine/Threonine-Protein Kinase Sak protein
PLK4 protein
SAK protein
STK18 protein

Information sourced from Uniprot.org

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