| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
PICK1 Positive Control for STJ505933 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
PICK1 |
| Gene ID: |
9463 |
| Uniprot ID: |
PICK1_HUMAN |
| Specificity: |
This is positive control is recommended for use in combination with PICK1 antibody STJ505933. |
| Immunogen: |
Purified PRKCA-binding protein/PICK1. |
| Post Translational Modifications | Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors. Palmitoylation on Cys-413 is essential for long-term synaptic depression (LTD). |
| Function | Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex.the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. |
| Peptide Name | Prkca-Binding ProteinProtein Interacting With C Kinase 1Protein Kinase C-Alpha-Binding Protein |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-416993 |
| Cellular Localisation | CytoplasmPerinuclear RegionMembranePeripheral Membrane ProteinLipid-AnchorPostsynaptic DensitySynapseSynaptosomeCytoskeletonAlso Membrane-AssociatedPresent At Excitatory Synapses |
| Alternative Peptide Names | Prkca-Binding Protein proteinProtein Interacting With C Kinase 1 proteinProtein Kinase C-Alpha-Binding Protein proteinPICK1 proteinPRKCABP protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
