| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
PGCF Positive Control for STJ502470 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: |
WB: 1:500 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Gucy2f |
| Gene ID: |
116556 |
| Uniprot ID: |
GUC2F_RAT |
| Specificity: |
This is positive control is recommended for use in combination with PGCF antibody STJ502470. |
| Tissue Specificity | Expressed only in the eye. |
| Post Translational Modifications | There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds. |
| Function | Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane. |
| Peptide Name | Retinal Guanylyl Cyclase 2Retgc-2Guanylate Cyclase 2f - RetinalGuanylate Cyclase FGc-FRod Outer Segment Membrane Guanylate Cyclase 2Ros-Gc2 |
| Database Links | Reactome: R-RNO-2514859 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinPhotoreceptor Outer Segment Membrane |
| Alternative Peptide Names | Retinal Guanylyl Cyclase 2 proteinRetgc-2 proteinGuanylate Cyclase 2f - Retinal proteinGuanylate Cyclase F proteinGc-F proteinRod Outer Segment Membrane Guanylate Cyclase 2 proteinRos-Gc2 proteinGucy2f proteinGuc2f protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
