| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
PGCE Positive Control for STJ502465 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: |
WB: 1:500 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Gucy2e |
| Gene ID: |
79222 |
| Uniprot ID: |
GUC2E_RAT |
| Specificity: |
This is positive control is recommended for use in combination with PGCE antibody STJ502465. |
| Tissue Specificity | Expressed in retina and enriched in photoreceptor outer segments. |
| Post Translational Modifications | There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds. |
| Function | Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane. |
| Peptide Name | Retinal Guanylyl Cyclase 1Retgc-1Guanylate Cyclase 2eGuanylyl Cyclase Gc-E |
| Database Links | Reactome: R-RNO-2514859 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinPhotoreceptor Outer Segment MembraneEndoplasmic Reticulum Membrane |
| Alternative Peptide Names | Retinal Guanylyl Cyclase 1 proteinRetgc-1 proteinGuanylate Cyclase 2e proteinGuanylyl Cyclase Gc-E proteinGucy2e proteinGuc2e proteinGucy2d protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
