PGCE Positive Control for STJ502465 peptide (STJ504707)

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STJ504707-5
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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : PGCE Positive Control for STJ502465 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Gucy2e
Gene ID: 79222
Uniprot ID: GUC2E_RAT
Specificity: This is positive control is recommended for use in combination with PGCE antibody STJ502465.
Tissue Specificity Expressed in retina and enriched in photoreceptor outer segments.
Post Translational Modifications There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds.
Function Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane.
Peptide Name Retinal Guanylyl Cyclase 1
Retgc-1
Guanylate Cyclase 2e
Guanylyl Cyclase Gc-E
Database Links Reactome: R-RNO-2514859
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Photoreceptor Outer Segment Membrane
Endoplasmic Reticulum Membrane
Alternative Peptide Names Retinal Guanylyl Cyclase 1 protein
Retgc-1 protein
Guanylate Cyclase 2e protein
Guanylyl Cyclase Gc-E protein
Gucy2e protein
Guc2e protein
Gucy2d protein

Information sourced from Uniprot.org

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