| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
PGCE Blocking Peptide for STJ502466 is synthetically produced from the C-Term sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Gucy2e |
| Gene ID: |
79222 |
| Uniprot ID: |
GUC2E_RAT |
| Immunogen Region: |
C-Term |
| Specificity: |
This blocking peptide is recommended for use in combination with PGCE antibody, STJ502466 |
| Immunogen: |
Synthetic C-terminal peptide corresponding to unique amino acid sequences on Particulate Guanylyl Cyclase E protein. |
| Tissue Specificity | Expressed in retina and enriched in photoreceptor outer segments. |
| Post Translational Modifications | There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds. |
| Function | Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane. |
| Peptide Name | Retinal Guanylyl Cyclase 1Retgc-1Guanylate Cyclase 2eGuanylyl Cyclase Gc-E |
| Database Links | Reactome: R-RNO-2514859 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinPhotoreceptor Outer Segment MembraneEndoplasmic Reticulum Membrane |
| Alternative Peptide Names | Retinal Guanylyl Cyclase 1 proteinRetgc-1 proteinGuanylate Cyclase 2e proteinGuanylyl Cyclase Gc-E proteinGucy2e proteinGuc2e proteinGucy2d protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
