PDE4A8 Blocking Peptide peptide (STJ504628)

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STJ504628-250
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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : PDE4A8 Blocking Peptide is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PDE4A
Gene ID: 5141
Uniprot ID: PDE4A_HUMAN
Immunogen: Synthetic peptide specific only for PDE4A8 protein.
Tissue Specificity Isoform 1: Expressed in lymphoid cell subsets including CD8-positive T cells and T-helper 2 cells. Expressed in dendritic cells. Isoform 2: Highly expressed in liver, stomach, testis, thyroid and adrenal glands and at a lower extent in placenta, kidney, pancreas, ovary, uterus and skin. Expressed in myeloid cell subsets including dendritic cells, monocytes, macrophages, eosinophils and mast cells. Expressed in natural killer cells. Expressed in bronchial smooth muscle. Isoform 6: Expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes. Isoform 7: Expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Found in specific neuronal subpopulations including cortical pyramidal neurons, horn neurons in the spinal cord and Purkinje cells in cerebellum (at protein level).
Post Translational Modifications Isoform 1: Proteolytically cleaved by CASP3. Isoform 2: Phosphorylated at Ser-119 by PKA.
Function Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. Isoform 1: Efficiently hydrolyzes cAMP. Isoform 2: Efficiently hydrolyzes cAMP. Isoform 3: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. Isoform 4: Efficiently hydrolyzes cAMP. Isoform 6: Efficiently hydrolyzes cAMP. Isoform 7: Efficiently hydrolyzes cAMP.
Peptide Name 3' -5'-Cyclic-Amp Phosphodiesterase 4a
Dpde2
Pde46
Camp-Specific Phosphodiesterase 4a
Database Links Reactome: R-HSA-180024
Reactome: R-HSA-418555
Cellular Localisation Isoform 1: Cytoplasm
Perinuclear Region
Isoform 2: Cytoplasm
Cell Projection
Ruffle Membrane
Isoform 3: Cytoplasm
Cytosol
Isoform 4: Membrane
Peripheral Membrane Protein
Isoform 4 Has Propensity For Association With Membranes
Isoform 6: Cytoplasm
Isoform 7: Cytoplasm
Membrane
Predominantly Cytosolic
Alternative Peptide Names 3' -5'-Cyclic-Amp Phosphodiesterase 4a protein
Dpde2 protein
Pde46 protein
Camp-Specific Phosphodiesterase 4a protein
PDE4A protein
DPDE2 protein

Information sourced from Uniprot.org

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