PDE10A Positive Control peptide (Phospho) (STJ504771)

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STJ504771-5
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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Phospho-PDE10A Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications.
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PDE10A
Gene ID: 10846
Uniprot ID: PDE10_HUMAN
Tissue Specificity Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.
Post Translational Modifications Isoform PDE10A2: Phosphorylated on Thr-16.
Function Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition.
Peptide Name Camp And Camp-Inhibited Cgmp 3' -5'-Cyclic Phosphodiesterase 10a
Database Links Reactome: R-HSA-418457
Reactome: R-HSA-418555
Cellular Localisation Cytoplasm
Cytosol
Alternative Peptide Names Camp And Camp-Inhibited Cgmp 3' -5'-Cyclic Phosphodiesterase 10a protein
PDE10A protein

Information sourced from Uniprot.org

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