| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
PD-L2 Blocking Peptide is synthetically produced from the 115-165 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
PDCD1LG2 |
| Gene ID: |
80380 |
| Uniprot ID: |
PD1L2_HUMAN |
| Immunogen Region: |
115-165 |
| Immunogen: |
Synthetic peptide taken within amino acid region 115-165 on human Programmed cell death 1 ligand 2 protein. |
| Tissue Specificity | Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus. |
| Function | Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. |
| Peptide Name | Programmed Cell Death 1 Ligand 2Pd-1 Ligand 2Pd-L2Pdcd1 Ligand 2Programmed Death Ligand 2Butyrophilin B7-DcB7-DcCd Antigen Cd273 |
| Database Links | Reactome: R-HSA-389948 |
| Cellular Localisation | Isoform 3: SecretedIsoform 2: Endomembrane SystemSingle-Pass Type I Membrane ProteinIsoform 1: Cell Membrane |
| Alternative Peptide Names | Programmed Cell Death 1 Ligand 2 proteinPd-1 Ligand 2 proteinPd-L2 proteinPdcd1 Ligand 2 proteinProgrammed Death Ligand 2 proteinButyrophilin B7-Dc proteinB7-Dc proteinCd Antigen Cd273 proteinPDCD1LG2 proteinB7DC proteinCD273 proteinPDCD1L2 proteinPDL2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
