| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
PAX5 Blocking Peptide for STJ502162 is synthetically produced from the 250-300 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
PAX5 |
| Gene ID: |
5079 |
| Uniprot ID: |
PAX5_HUMAN |
| Immunogen Region: |
250-300 |
| Specificity: |
This blocking peptide is recommended for use in combination with PAX5 antibody, STJ502162 |
| Immunogen: |
Synthetic peptide taken within amino acid region 250-300 on human PAX5 protein. |
| Post Translational Modifications | O-glycosylated. Phosphorylated by SYK. This phosphorylation plays an important role in the abolition of BLIMP1 repression by PAX5 in order to trigger plasma cell differentiation. |
| Function | Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage. Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes. In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage. Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire. (Microbial infection) Plays an essential role in the maintenance of Epstein-Barr virus genome copy number within the host cell by promoting EBNA1/oriP-dependent binding and transcription. Participates also in the inhibition of lytic EBV reactivation by modulating viral BZLF1 activity. |
| Peptide Name | Paired Box Protein Pax-5B-Cell-Specific Transcription FactorBsap |
| Database Links | Reactome: R-HSA-8939245 |
| Cellular Localisation | Nucleus |
| Alternative Peptide Names | Paired Box Protein Pax-5 proteinB-Cell-Specific Transcription Factor proteinBsap proteinPAX5 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
