| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Pannexin 1 Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: |
WB: 1:500 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Tissue Specificity | Widely expressed. Highest expression is observed in oocytes and brain. Detected at very low levels in sperm cells. |
| Post Translational Modifications | S-nitrosylation inhibits channel currents and ATP release. N-glycosylation may play a role in cell surface targeting. Exists in three glycosylation states: non-glycosylated (GLY0), high-mannose glycosylated (GLY1), and fully mature glycosylated (GLY2). |
| Function | Structural component of the gap junctions and the hemichannels involved in the ATP release and nucleotide permeation. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis. Plays a critical role in oogenesis. |
| Peptide Name | Pannexin-1 |
| Database Links | Reactome: R-HSA-112303Reactome: R-HSA-844456 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell JunctionGap JunctionEndoplasmic Reticulum Membrane |
| Alternative Peptide Names | Pannexin-1 proteinPANX1 proteinMRS1 proteinUNQ2529 proteinPRO6028 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
