| Applications: | Immunodepletion/Immunocompetition |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | p63 Blocking Peptide is synthetically produced from the 1-100 sequence and is suitable for use in western blot applications. |
| Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | TP63 |
| Gene ID: | 8626 |
| Uniprot ID: | P63_HUMAN |
| Immunogen Region: | 1-100 |
| Immunogen: | Synthetic peptide taken within amino acid region 1-100 on human p63 protein. |
| Tissue Specificity | Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues. |
| Post Translational Modifications | May be sumoylated. Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein. |
| Function | Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. |
| Peptide Name | Tumor Protein 63 P63 Chronic Ulcerative Stomatitis Protein Cusp Keratinocyte Transcription Factor Ket Transformation-Related Protein 63 Tp63 Tumor Protein P73-Like P73l P40 P51 |
| Database Links | Reactome: R-HSA-139915 Reactome: R-HSA-5620971 Reactome: R-HSA-5628897 Reactome: R-HSA-6803204 Reactome: R-HSA-6803205 Reactome: R-HSA-6803207 Reactome: R-HSA-6803211 Reactome: R-HSA-6804759 Reactome: R-HSA-9725554 |
| Cellular Localisation | Nucleus |
| Alternative Peptide Names | Tumor Protein 63 protein P63 protein Chronic Ulcerative Stomatitis Protein protein Cusp protein Keratinocyte Transcription Factor Ket protein Transformation-Related Protein 63 protein Tp63 protein Tumor Protein P73-Like protein P73l protein P40 protein P51 protein TP63 protein KET protein P63 protein P73H protein P73L protein TP73L protein |
Information sourced from Uniprot.org