| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Olig2 Blocking Peptide is synthetically produced from the 136-156 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
OLIG2 |
| Gene ID: |
10215 |
| Uniprot ID: |
OLIG2_HUMAN |
| Immunogen Region: |
136-156 |
| Immunogen: |
Synthetic peptide corresponding to Human Olig2 amino acids 136-156. The selected peptide was post-synthetically modified to achieve highest antigenicity before coupling to a carrier protein using hetero-bifunctional cross linker for immunogen prepara |
| Tissue Specificity | Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. |
| Function | Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. |
| Peptide Name | Oligodendrocyte Transcription Factor 2Oligo2Class B Basic Helix-Loop-Helix Protein 1Bhlhb1Class E Basic Helix-Loop-Helix Protein 19Bhlhe19Protein Kinase C-Binding Protein 2Protein Kinase C-Binding Protein Rack17 |
| Cellular Localisation | NucleusCytoplasmThe Nls Contained In The Bhlh Domain Could Be Masked In The Native Form And Translocation To The Nucleus Could Be Mediated By Interaction Either With Class E Bhlh Partner Protein Or With Nkx2-2 |
| Alternative Peptide Names | Oligodendrocyte Transcription Factor 2 proteinOligo2 proteinClass B Basic Helix-Loop-Helix Protein 1 proteinBhlhb1 proteinClass E Basic Helix-Loop-Helix Protein 19 proteinBhlhe19 proteinProtein Kinase C-Binding Protein 2 proteinProtein Kinase C-Binding Protein Rack17 proteinOLIG2 proteinBHLHB1 proteinBHLHE19 proteinPRKCBP2 proteinRACK17 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
