Nicotinic Acetylcholine Receptor alpha 7 Blocking Peptide peptide (STJ504399)

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STJ504399-250
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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Nicotinic Acetylcholine Receptor alpha 7 Blocking Peptide is synthetically produced from the 25-75 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Chrna7
Gene ID: 25302
Uniprot ID: ACHA7_RAT
Immunogen Region: 25-75
Immunogen: Synthetic peptide taken within amino acid region 25-75 on mouse GTPCHI protein.
Post Translational Modifications Glycosylations at Asn-46, Asn-90 and Asn-133 are essential for TMEM35A/NACHO-mediated proper subunit assembly and trafficking to the cell membrane.
Function After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
Peptide Name Neuronal Acetylcholine Receptor Subunit Alpha-7
Database Links Reactome: R-RNO-629594
Cellular Localisation Postsynaptic Cell Membrane
Multi-Pass Membrane Protein
Cell Membrane
Ric3 Promotes Its Trafficking To The Cell Membrane
Tmem35a/Nacho Promotes Its Trafficking To The Cell Membrane
Alternative Peptide Names Neuronal Acetylcholine Receptor Subunit Alpha-7 protein
Chrna7 protein
Acra7 protein

Information sourced from Uniprot.org

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