| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Nicotinic Acetylcholine Receptor alpha 7 Blocking Peptide is synthetically produced from the 25-75 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Chrna7 |
| Gene ID: |
25302 |
| Uniprot ID: |
ACHA7_RAT |
| Immunogen Region: |
25-75 |
| Immunogen: |
Synthetic peptide taken within amino acid region 25-75 on mouse GTPCHI protein. |
| Post Translational Modifications | Glycosylations at Asn-46, Asn-90 and Asn-133 are essential for TMEM35A/NACHO-mediated proper subunit assembly and trafficking to the cell membrane. |
| Function | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. |
| Peptide Name | Neuronal Acetylcholine Receptor Subunit Alpha-7 |
| Database Links | Reactome: R-RNO-629594 |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinCell MembraneRic3 Promotes Its Trafficking To The Cell MembraneTmem35a/Nacho Promotes Its Trafficking To The Cell Membrane |
| Alternative Peptide Names | Neuronal Acetylcholine Receptor Subunit Alpha-7 proteinChrna7 proteinAcra7 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
