| Post Translational Modifications | N-glycosylated. O-glycosylated. Phosphorylated on serine residues. |
| Function | Low affinity neurotrophin receptor which can bind to mature NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF (proNGF), BDNF (proBDNF) and NTF3 (proNT3) with high affinity, and has much lower affinity for mature NGF and BDNF. Plays an important role in differentiation and survival of specific neuronal populations during development. Can mediate cell survival as well as cell death of neural cells. The heterodimeric receptor formed with SORCS2 plays a role in proBDNF-dependent synaptic plasticity, in hippocampal long term depression (LTD) and long term potentiation (LTP). Plays a role in the inactivation of RHOA. Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake. Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver. (Microbial infection) Cell surface receptor for rabies virus glycoprotein Gs. Isoform 2: Does not bind NGF, BDNF, NTF3, and NTF4. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 16Low Affinity Neurotrophin Receptor P75ntrLow-Affinity Nerve Growth Factor ReceptorNgf ReceptorLow-Affinity Nerve Growth Factor Receptor P75ngfrLow-Affinity Nerve Growth Factor Receptor P75ngrCd Antigen Cd271 |
| Database Links | Reactome: R-MMU-193634Reactome: -MMU-193692Reactome: -MMU-205017Reactome: -MMU-205025Reactome: -MMU-205043Reactome: -MMU-209543Reactome: -MMU-209560Reactome: -MMU-209563 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCytoplasmPerikaryonCell ProjectionGrowth ConeDendritic Spine |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 16 proteinLow Affinity Neurotrophin Receptor P75ntr proteinLow-Affinity Nerve Growth Factor Receptor proteinNgf Receptor proteinLow-Affinity Nerve Growth Factor Receptor P75ngfr proteinLow-Affinity Nerve Growth Factor Receptor P75ngr proteinCd Antigen Cd271 proteinNgfr proteinTnfrsf16 protein |
Information sourced from Uniprot.org
