| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Netrin 1 Blocking Peptide is synthetically produced from the 250-300 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
NTN1 |
| Gene ID: |
9423 |
| Uniprot ID: |
NET1_HUMAN |
| Immunogen Region: |
250-300 |
| Immunogen: |
Synthetic peptide taken within amino acid region 250-300 on human Netrin-1 protein. |
| Tissue Specificity | Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas. Expressed in epididymis (at protein level). |
| Function | Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Involved in dorsal root ganglion axon projection towards the spinal cord. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis. |
| Peptide Name | Netrin-1Epididymis Tissue Protein Li 131p |
| Database Links | Reactome: R-HSA-373752Reactome: R-HSA-376172Reactome: R-HSA-418885Reactome: R-HSA-418886Reactome: R-HSA-418890Reactome: R-HSA-428542 |
| Cellular Localisation | SecretedCytoplasmMainly Secreted |
| Alternative Peptide Names | Netrin-1 proteinEpididymis Tissue Protein Li 131p proteinNTN1 proteinNTN1L protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
