MURF1 Blocking Peptide peptide (STJ504391)

SKU:
STJ504391-250

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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: MURF1 Blocking Peptide is synthetically produced from the 270-310 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: TRIM63
Gene ID: 84676
Uniprot ID: TRI63_HUMAN
Immunogen Region: 270-310
Immunogen: Synthetic peptide taken wtihin amino acid region 270-310 on human MURF1 protein.
Tissue Specificity Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris.
Function E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
Peptide Name E3 Ubiquitin-Protein Ligase Trim63
Iris Ring Finger Protein
Muscle-Specific Ring Finger Protein 1
Murf-1
Murf1
Ring Finger Protein 28
Ring-Type E3 Ubiquitin Transferase Trim63
Striated Muscle Ring Zinc Finger Protein
Tripartite Motif-Containing Protein 63
Database Links Reactome: R-HSA-9615017
Reactome: R-HSA-983168
Cellular Localisation Cytoplasm
Nucleus
Myofibril
Sarcomere
M Line
Z Line
Colocalizes With Tnni3 In Myocytes
Localizes To The M- And Z-Lines In Skeletal Muscle
Alternative Peptide Names E3 Ubiquitin-Protein Ligase Trim63 protein
Iris Ring Finger Protein protein
Muscle-Specific Ring Finger Protein 1 protein
Murf-1 protein
Murf1 protein
Ring Finger Protein 28 protein
Ring-Type E3 Ubiquitin Transferase Trim63 protein
Striated Muscle Ring Zinc Finger Protein protein
Tripartite Motif-Containing Protein 63 protein
TRIM63 protein
IRF protein
MURF1 protein
RNF28 protein
SMRZ protein

Information sourced from Uniprot.org

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