| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
MURF1 Blocking Peptide is synthetically produced from the 270-310 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
TRIM63 |
| Gene ID: |
84676 |
| Uniprot ID: |
TRI63_HUMAN |
| Immunogen Region: |
270-310 |
| Immunogen: |
Synthetic peptide taken wtihin amino acid region 270-310 on human MURF1 protein. |
| Tissue Specificity | Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris. |
| Function | E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells. |
| Peptide Name | E3 Ubiquitin-Protein Ligase Trim63Iris Ring Finger ProteinMuscle-Specific Ring Finger Protein 1Murf-1Murf1Ring Finger Protein 28Ring-Type E3 Ubiquitin Transferase Trim63Striated Muscle Ring Zinc Finger ProteinTripartite Motif-Containing Protein 63 |
| Database Links | Reactome: R-HSA-9615017Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleusMyofibrilSarcomereM LineZ LineColocalizes With Tnni3 In MyocytesLocalizes To The M- And Z-Lines In Skeletal Muscle |
| Alternative Peptide Names | E3 Ubiquitin-Protein Ligase Trim63 proteinIris Ring Finger Protein proteinMuscle-Specific Ring Finger Protein 1 proteinMurf-1 proteinMurf1 proteinRing Finger Protein 28 proteinRing-Type E3 Ubiquitin Transferase Trim63 proteinStriated Muscle Ring Zinc Finger Protein proteinTripartite Motif-Containing Protein 63 proteinTRIM63 proteinIRF proteinMURF1 proteinRNF28 proteinSMRZ protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
