| Post Translational Modifications | Ubiquitinated at Lys-839 by MYLIP leading to degradation. |
| Function | Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Binds also to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE-containing ligands as well as clusterin/CLU. In the off-state of the pathway LRP8 and VLDLR form homo or heterooligomers. Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 on its cytoplasmic tail. This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons. Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone. |
| Protein Name | Very Low-Density Lipoprotein ReceptorVldl ReceptorVldl-R |
| Database Links | Reactome: R-MMU-8866376Reactome: -MMU-8866427Reactome: -MMU-8964046 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinClathrin-Coated Pit |
| Alternative Protein Names | Very Low-Density Lipoprotein Receptor proteinVldl Receptor proteinVldl-R proteinVldlr protein |
Information sourced from Uniprot.org
