| Post Translational Modifications | Autophosphorylated. |
| Function | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. |
| Protein Name | Tyrosine-Protein Kinase Receptor Tyro3Etk2/Tyro3Tk19-2Tyrosine-Protein Kinase DtkTyrosine-Protein Kinase RseTyrosine-Protein Kinase Tif |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Tyrosine-Protein Kinase Receptor Tyro3 proteinEtk2/Tyro3 proteinTk19-2 proteinTyrosine-Protein Kinase Dtk proteinTyrosine-Protein Kinase Rse proteinTyrosine-Protein Kinase Tif proteinTyro3 proteinDtk proteinRse proteinTif protein |
Information sourced from Uniprot.org
