| Function | Positively regulates Toll-like receptor signaling via TLR7, TLR9 and TLR13 in neutrophils and splenic macrophages. Regulates TLR7 signaling by controlling ligand-induced recruitment of TLR7 from the endoplasmic reticulum to endosomes and lysosomes. Positively regulates Toll-like receptor TLR9-induced production of inflammatory cytokines but is dispensable for IFNB1 production. Involved in the anti-viral response to several viruses including influenza virus, vesicular stomatitis virus and cytomegalovirus. Binds to late apoptotic, and necrotic cells, but not living or early apoptotic cells, but is not essential for uptake of dying cells by dendritic cells (DCs). Does not bind nucleic acids. May participate in antigen presentation. |
| Protein Name | Trem-Like Transcript 4 ProteinTlt-4Triggering Receptor Expressed On Myeloid Cells-Like Protein 3Triggering Receptor Expressed On Myeloid Cells-Like Protein 4 |
| Database Links | Reactome: R-MMU-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Trem-Like Transcript 4 Protein proteinTlt-4 proteinTriggering Receptor Expressed On Myeloid Cells-Like Protein 3 proteinTriggering Receptor Expressed On Myeloid Cells-Like Protein 4 proteinTreml4 proteinTLT4 proteinTreml3 protein |
Information sourced from Uniprot.org
