| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Mouse TP53/p53-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | Tp53 |
| Gene ID: | 22059 |
| Uniprot ID: | P53_MOUSE |
| Immunogen Region: | Met1-Asp390 |
| Immunogen: | Mus musculus (Mouse) |
| Function | Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types.induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2. However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis.the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis, but seems to have to effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2. |
| Protein Name | Cellular Tumor Antigen P53Tumor Suppressor P53 |
| Database Links | Reactome: R-MMU-2559580Reactome: -MMU-2559584Reactome: -MMU-2559585Reactome: -MMU-2559586Reactome: -MMU-349425Reactome: -MMU-5689880Reactome: -MMU-5689896Reactome: -MMU-5693565Reactome: -MMU-6804754Reactome: -MMU-6804756Reactome: -MMU-6804757Reactome: -MMU-6804758Reactome: -MMU-6804759Reactome: -MMU-6804760Reactome: -MMU-6811555Reactome: -MMU-69473Reactome: -MMU-69481Reactome: -MMU-69541Reactome: -MMU-69895Reactome: -MMU-8852276Reactome: -MMU-8941855Reactome: -MMU-9833482 |
| Cellular Localisation | CytoplasmNucleusPml BodyEndoplasmic ReticulumMitochondrion MatrixCytoskeletonMicrotubule Organizing CenterCentrosomeInteraction With Banp Promotes Nuclear LocalizationRecruited Into Pml Bodies Together With Chek2Translocates To Mitochondria Upon Oxidative StressTranslocates To Mitochondria In Response To Mitomycin C TreatmentCompetitive Inhibition Of Tp53 Interaction With Hspa9/Mot-2 By Ubxn2a Results In Increased Protein Abundance And Subsequent Translocation Of Tp53 To The Nucleus |
| Alternative Protein Names | Cellular Tumor Antigen P53 proteinTumor Suppressor P53 proteinTp53 proteinP53 proteinTrp53 protein |
Information sourced from Uniprot.org