Mouse TNFSF18 protein (Recombinant) (N-His) (STJP009112)

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STJP009112
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse TNFSF18-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: Tnfsf18
Gene ID: 240873
Uniprot ID: TNF18_MOUSE
Immunogen Region: Glu50-Ser173
Immunogen: Mus musculus (Mouse)
Post Translational Modifications N-glycosylated.
Function Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. Promotes leukocyte adhesion to endothelial cells. Regulates migration of monocytes from the splenic reservoir to sites of inflammation.
Protein Name Tumor Necrosis Factor Ligand Superfamily Member 18
Gitr Ligand
Gitrl
Glucocorticoid-Induced Tnf-Related Ligand
Database Links Reactome: R-MMU-5669034
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Alternative Protein Names Tumor Necrosis Factor Ligand Superfamily Member 18 protein
Gitr Ligand protein
Gitrl protein
Glucocorticoid-Induced Tnf-Related Ligand protein
Tnfsf18 protein
Gitrl protein

Information sourced from Uniprot.org

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