| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from 0.22 Mu m filtered solution in 20mM PB, 300mM NaCl (pH 7.0). Normally 8% Trehalose is added as protectant before lyophilisation. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <1 EU/ug of the protein by LAL method |
| Immunoreactivity: | Measured by its ability to induce apoptosis of TF‑1 human erythroleukemic cells. The ED50 for this effect is 15.61-62.44 ng/mL, corresponding to a specific activity of 1.60×104~6.41×104 units/mg. |
| Gene Symbol: | Tnfsf15 |
| Gene ID: | 326623 |
| Uniprot ID: | TNF15_MOUSE |
| Immunogen Region: | Ile76-Leu252 |
| Immunogen: | Recombinant Recombinant Mouse TNFSF15/TL1A Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ile76-Leu252) of Mouse TNFSF15/TL1A (Accession #NP_796345.3) fused with no tag. |
| Immunogen Sequence: | GTLPKPTLWAEPASVIARGK PVTLWCQGPLETEEYRLDKE GLPWARKRQNPLEPGAKAKF HIPSTVYDSAGRYRCYYETP AGWSEPSDPLELVATGFYAE PTLLALPSPVVASGGNVTLQ CDTLDGLLTFVLVEEEQKLP RTLYSQKLPKGPSQALFPVG PVTPSCRWRFRCYYYYRKNP QVWSNPSDLLEILVPGVSRK PSLLIPQGSVVARGGSLTLQ CRSDVGYDIFVLYKEGEHD |
| Function | Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. Promotes splenocyte alloactivation. |
| Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 15Tnf Ligand-Related Molecule 1Vascular Endothelial Cell Growth Inhibitor |
| Database Links | Reactome: R-MMU-5669034 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Tumor Necrosis Factor Ligand Superfamily Member 15 proteinTnf Ligand-Related Molecule 1 proteinVascular Endothelial Cell Growth Inhibitor proteinTnfsf15 proteinTl1 proteinVegi protein |
Information sourced from Uniprot.org