| Host: |
E.coli |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
<0.01 EU/Mu g of the protein by LAL method. |
| Gene Symbol: |
Tnfsf13b |
| Gene ID: |
24099 |
| Uniprot ID: |
TN13B_MOUSE |
| Immunogen Region: |
Ala127-Leu309 |
| Immunogen: |
Recombinant Mouse TNFSF13B/BAFF/CD257 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala127-Leu309) of Mouse TNFSF13B/BAFF/CD257 (Accession #NP_296371.1) fused with a His and a hFc tag at the N-t |
| Immunogen Sequence: |
MADDQGCIEEQGVEDSANED SVDAKPDRSSFVPSLFSKKK KNVTMRSIKTTRDRVPTYQY NMNFEKLGKCIIINNKNFDK VTGMGVRNGTDKDAEALFKC FRSLGFDVIVYNDCSCAKMQ DLLKKASEEDHTNAACFACI LLSHGEENVIYGKDGVTPIK DLTAHFRGDRCKTLLEKPKL FFIQACRGTELDDGIQADSG PINDTDANPRYKIPVEADFL FAYSTVPGYYSWRSPGRGS |
| Tissue Specificity | Isoform 2 is expressed in many myeloid cell lines. |
| Post Translational Modifications | The soluble form derives from the membrane form by proteolytic processing. Isoform 2 is not efficiently shed from the membrane unlike isoform 1. |
| Function | Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. |
| Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 13bB-Cell-Activating FactorBaffCd Antigen Cd257 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 13b - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 13b - Soluble Form |
| Database Links | Reactome: R-MMU-5668541Reactome: -MMU-5669034Reactome: -MMU-5676594 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinTumor Necrosis Factor Ligand Superfamily Member 13bSoluble Form: Secreted |
| Alternative Protein Names | Tumor Necrosis Factor Ligand Superfamily Member 13b proteinB-Cell-Activating Factor proteinBaff proteinCd Antigen Cd257 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 13b - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 13b - Soluble Form proteinTnfsf13b proteinBaff protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
