| Tissue Specificity | In thymus and spleen, but not in non-lymphoid tissues. Expressed on myeloid progenitor cells. |
| Post Translational Modifications | Phosphorylated. N-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. |
| Function | Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells. Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory. In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis. Negatively regulates the function of Th2 lymphocytes in the adipose tissue. |
| Protein Name | Cd27 AntigenCd27l ReceptorT-Cell Activation Antigen Cd27Tumor Necrosis Factor Receptor Superfamily Member 7Cd Antigen Cd27 |
| Database Links | Reactome: R-MMU-5669034 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Cd27 Antigen proteinCd27l Receptor proteinT-Cell Activation Antigen Cd27 proteinTumor Necrosis Factor Receptor Superfamily Member 7 proteinCd Antigen Cd27 proteinCd27 proteinTnfrsf7 protein |
Information sourced from Uniprot.org
