Mouse TIMP1 protein (Recombinant) (N-His) (STJP009790)

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STJP009790
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse TIMP1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: Timp1
Gene ID: 21857
Uniprot ID: TIMP1_MOUSE
Immunogen Region: His31-Arg205
Immunogen: Mus musculus (Mouse)
Post Translational Modifications The activity of TIMP1 is dependent on the presence of disulfide bonds. N-glycosylated.
Function Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling.
Protein Name Metalloproteinase Inhibitor 1
Collagenase Inhibitor 16c8 Fibroblast
Erythroid-Potentiating Activity
Epa
Tpa-S1
Tpa-Induced Protein
Tissue Inhibitor Of Metalloproteinases 1
Timp-1
Database Links Reactome: R-MMU-114608
Reactome: -MMU-1592389
Reactome: -MMU-381426
Reactome: -MMU-8957275
Reactome: -MMU-9839383
Cellular Localisation Secreted
Alternative Protein Names Metalloproteinase Inhibitor 1 protein
Collagenase Inhibitor 16c8 Fibroblast protein
Erythroid-Potentiating Activity protein
Epa protein
Tpa-S1 protein
Tpa-Induced Protein protein
Tissue Inhibitor Of Metalloproteinases 1 protein
Timp-1 protein
Timp1 protein
Timp protein
Timp-1 protein

Information sourced from Uniprot.org

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