| Short Description : | Recombinant-Mouse TIGIT-C-mFc&His protein was developed in hek293 cells using the region Gly26-Gly141. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized Mouse CD155 at 2 Mu g/mL (100 Mu L/well) can bind Mouse TIGIT with a linear range of 2-50 ng/mL. |
| Determination Method: | <0.1 EU/Mu g |
| Gene Symbol: | TigitUniprot ID=TIGIT_MOUSE" |
| Immunogen: | Recombinant Human TIGIT Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly26-Gly141) of human TIGIT (Accession #NP_001139797.1) fused with a mFc, 6×His tag at the C-terminus. |
| Immunogen Region: | Gly26-Gly141 |
| Immunogen Sequence: | GTIDTKRNISAEEGGSVILQ CHFSSDTAEVTQVDWKQQDQ LLAIYSVDLGWHVASVFSDR VVPGPSLGLTFQSLTMNDTG EYFCTYHTYPGGIYKGRIFL KVQESSVAQFQTAPLG |
| Protein Name | T-Cell Immunoreceptor With Ig And Itim DomainsV-Set And Transmembrane Domain-Containing Protein 3 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinClustered To The Immunological Synapse Where It Disrupts Granule Polarization And Cytotoxicity Of Nk Cells Once Engaged With Pvr |
| Alternative Protein Names | T-Cell Immunoreceptor With Ig And Itim Domains proteinV-Set And Transmembrane Domain-Containing Protein 3 proteinTigit proteinVstm3 protein |
Information sourced from Uniprot.org
