Mouse TGFBR2/TGFR-2 protein (Recombinant) (N-His-SUMO) (STJP009867)

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STJP009867
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse TGFBR2/TGFR-2-N-His-SUMO protein was developed from e. coli and has a target region of N-His-SUMO. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: Tgfbr2
Gene ID: 21813
Uniprot ID: TGFR2_MOUSE
Immunogen Region: Cys71-Val163
Immunogen: Mus musculus (Mouse)
Post Translational Modifications Phosphorylated on a Ser/Thr residue in the cytoplasmic domain.
Function Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. Isoform RII-1: Has transforming growth factor beta-activated receptor activity. Isoform RII-2: Has transforming growth factor beta-activated receptor activity.
Protein Name Tgf-Beta Receptor Type-2
Tgfr-2
Tgf-Beta Type Ii Receptor
Transforming Growth Factor-Beta Receptor Type Ii
Tgf-Beta Receptor Type Ii
Tbetar-Ii
Database Links Reactome: R-MMU-2173788
Reactome: -MMU-2173789
Reactome: -MMU-2173791
Reactome: -MMU-9839389
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Membrane Raft
Alternative Protein Names Tgf-Beta Receptor Type-2 protein
Tgfr-2 protein
Tgf-Beta Type Ii Receptor protein
Transforming Growth Factor-Beta Receptor Type Ii protein
Tgf-Beta Receptor Type Ii protein
Tbetar-Ii protein
Tgfbr2 protein

Information sourced from Uniprot.org

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