Mouse TGFBR2/TGFR-2 protein (Recombinant-Active) (C-hFc-His) (STJP012153)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenMus musculus (Mouse)
General Information
| Short Description | Recombinant-Active-Mouse TGFBR2/TGFR-2-C-hFc-His protein was developed from mammalian cells and has a target region of C-hFc-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by its ability to inhibit TGF-beta 1 activity on mouse T cells (HT‑2). The ED50 for this effect is 3-10 ng/mL in the presence of 1 ng/mL of rhTGF beta 1. |
Target Information
| Gene Symbol | Tgfbr2 |
| Gene ID | 21813 |
| Uniprot ID | TGFR2_MOUSE |
| Immunogen | Mus musculus (Mouse) |
| Immunogen Region | Ile24-Asp184 (Isoform 2) |
Additional Info
| Post Translational Modifications | Phosphorylated on a Ser/Thr residue in the cytoplasmic domain. |
| Function | Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. Isoform RII-1: Has transforming growth factor beta-activated receptor activity. Isoform RII-2: Has transforming growth factor beta-activated receptor activity. |
| Protein Name | Tgf-Beta Receptor Type-2Tgfr-2Tgf-Beta Type Ii ReceptorTransforming Growth Factor-Beta Receptor Type IiTgf-Beta Receptor Type IiTbetar-Ii |
| Database Links | Reactome: R-MMU-2173788Reactome: -MMU-2173789Reactome: -MMU-2173791Reactome: -MMU-9839389 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane Raft |
| Alternative Protein Names | Tgf-Beta Receptor Type-2 proteinTgfr-2 proteinTgf-Beta Type Ii Receptor proteinTransforming Growth Factor-Beta Receptor Type Ii proteinTgf-Beta Receptor Type Ii proteinTbetar-Ii proteinTgfbr2 protein |
Information sourced from Uniprot.org