Post Translational Modifications | Gamma-carboxylation is controversial. Gamma-carboxyglutamated.gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation.this may be required for calcium binding. According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues. The EMI domain contains 2 expected intradomain disulfide bridges (Cys-49-Cys85 and Cys-84-Cys-97) and one unusual interdomain disulfide bridge to the second FAS1 domain (Cys-74-Cys-339). This arrangement violates the predicted disulfide bridge pattern of an EMI domain. |
Function | Plays a role in cell adhesion. May play a role in cell-collagen interactions. |
Protein Name | Transforming Growth Factor-Beta-Induced Protein Ig-H3Beta Ig-H3 |
Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixMay Be Associated Both With Microfibrils And With The Cell Surface |
Alternative Protein Names | Transforming Growth Factor-Beta-Induced Protein Ig-H3 proteinBeta Ig-H3 proteinTgfbi protein |
Information sourced from Uniprot.org