Mouse TGFB2/TGF-beta-2 protein (Recombinant-Active) (N-NA 8*His) (STJP011947)

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STJP011947-100
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Covered by St John's Laboratory Guarantee

Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Mouse TGFB2/TGF-beta-2-N-8*His protein was developed from mammalian cells and has a target region of N-8*His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: Tgfb2
Gene ID: 21808
Uniprot ID: TGFB2_MOUSE
Immunogen Region: Leu21-Ser414
Immunogen: Mus musculus (Mouse)
Function Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Latency-associated peptide: Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development. Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus. Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal.
Protein Name Transforming Growth Factor Beta-2 Proprotein Cleaved Into - Latency-Associated Peptide
Lap - Transforming Growth Factor Beta-2
Tgf-Beta-2
Database Links Reactome: R-MMU-114608
Reactome: -MMU-2129379
Reactome: -MMU-2173789
Reactome: -MMU-9839389
Cellular Localisation Latency-Associated Peptide: Secreted
Extracellular Space
Extracellular Matrix
Transforming Growth Factor Beta-2: Secreted
Alternative Protein Names Transforming Growth Factor Beta-2 Proprotein Cleaved Into - Latency-Associated Peptide protein
Lap - Transforming Growth Factor Beta-2 protein
Tgf-Beta-2 protein
Tgfb2 protein

Information sourced from Uniprot.org

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