| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.1 EU/Mu g |
| Immunoreactivity: | Measured by its ability to inhibit trypsin cleavage of a fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK (Dnp)-NH2 (RD, Catalog # ES002). The IC50 value is <0.26 nM, as measured under the described conditions. |
| Gene Symbol: | Tfpi |
| Gene ID: | 21788 |
| Uniprot ID: | TFPI1_MOUSE |
| Immunogen Region: | Leu 29-Asn306 |
| Immunogen: | Recombinant Mouse TFPI Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu 29-Asn306) of mouse TFPI (Accession #NP_035706.1) fused with and a 6×His tag at the C-terminus. |
| Immunogen Sequence: | LSEEADDTDSELGSMKPLHT FCAMKADDGPCKAMIRSYFF NMYTHQCEEFIYGGCEGNEN RFDTLEECKKTCIPGYEKTA VKAASGAERPDFCFLEEDPG LCRGYMKRYLYNNQTKQCER FVYGGCLGNRNNFETLDECK KICENPVHSPSPVNEVQMSD YVTDGNTVTDRSTVNNIVVP QSPKVPRRRDYRGRPWCLQP ADSGLCKASERRFYYNSATG KCHRFNYTGCGGNNNNFTT |
| Function | Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. |
| Protein Name | Tissue Factor Pathway Inhibitor Tfpi Extrinsic Pathway Inhibitor Epi Lipoprotein-Associated Coagulation Inhibitor Laci |
| Database Links | Reactome: R-MMU-140834 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Tissue Factor Pathway Inhibitor protein Tfpi protein Extrinsic Pathway Inhibitor protein Epi protein Lipoprotein-Associated Coagulation Inhibitor protein Laci protein Tfpi protein |
Information sourced from Uniprot.org