| Tissue Specificity | Expressed in skeletal muscle, heart, colon, stomach, uterus and lung. Expression is restricted to muscle cell layers in colon, uterus and stomach. |
| Post Translational Modifications | Phosphorylated by PKA, and by CaMK2 at multiple sites. Dephosphorylated by calcineurin at Ser-555 and Thr-602.abrogating interaction with YWHAB and impairing nuclear import. |
| Function | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks. At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension.may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes. Involved in regulation of cell migration. May be a tumor suppressor. |
| Protein Name | Synaptopodin-2Myopodin |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmMyofibrilSarcomereZ LineCell JunctionFocal AdhesionShuttles Between The Nucleus And The Cytoplasm In A Differentiation-Dependent And Stress-Induced FashionIn Undifferentiated Myoblasts Strongly Expressed In The NucleusAfter Induction Of Myotube Differentiation Is Located To Both Nucleus And Cytoplasm Along Acting FilamentsAnd In Differentiated Myotubes Is Located At The Z LinesUpon Stress Redistributes From Cytoplasm Of Myoblasts And Myotubes To The NucleusNuclear Import Is Kpna2-Dependent And Promoted By Phosphorylation By Pka And/Or Camk2And Inhibition Of CalcineurinThe Nuclear Export Is Xpo1-Dependent |
| Alternative ELISA Names | Synaptopodin-2 ELISA kitMyopodin ELISA kitSynpo2 ELISA kit |
| output | |
Information sourced from Uniprot.org
