| Host: |
HEK293 cells |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Mouse sTfR/CD71-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Mouse sTfR/CD71 at 5 Mu g/mL (100 Mu L/well) can bind Mouse Transferrin/TF with a linear range of 0.002-1.8 ng/mL. |
| Gene Symbol: |
Tfrc |
| Gene ID: |
22042 |
| Uniprot ID: |
TFR1_MOUSE |
| Immunogen: |
Recombinant Mouse sTfR/CD71 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Cys89-Phe763) of mouse Transferrin R/CD71 (Accession #NP_035768.1) fused with a 6×His tag at the C-terminus. |
| Function | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Upon stimulation, positively regulates T and B cell proliferation through iron uptake. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway. When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion. When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2. |
| Protein Name | Transferrin Receptor Protein 1TrTfrTfr1TrfrCd Antigen Cd71 |
| Database Links | Reactome: R-MMU-432722Reactome: -MMU-8856825Reactome: -MMU-8856828Reactome: -MMU-8980692Reactome: -MMU-9013026Reactome: -MMU-9013106Reactome: -MMU-9013149Reactome: -MMU-9013404Reactome: -MMU-9013406Reactome: -MMU-9013407Reactome: -MMU-9013408Reactome: -MMU-9013423Reactome: -MMU-917977Reactome: -MMU-9696270Reactome: -MMU-9696273 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinMelanosome |
| Alternative Protein Names | Transferrin Receptor Protein 1 proteinTr proteinTfr proteinTfr1 proteinTrfr proteinCd Antigen Cd71 proteinTfrc proteinTrfr protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
