| Short Description : | Recombinant-Mouse SR-D1/CD68-C-hFC protein was developed in hek293 cells using the region Asp21 –Ser291. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.2 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.01 EU/Mu g of the protein by LAL method |
| Gene Symbol: | Cd68 |
| Gene ID: | 12514 |
| Uniprot ID: | CD68_MOUSE |
| Immunogen: | Recombinant Mouse SR-D1/CD68 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp21 –Ser291) of Mouse SR-D1/CD68 (Accession #NP_001277987.1) fused with hFC at the C-terminus. |
| Immunogen Region: | Asp21 –Ser291 |
| Immunogen Sequence: | DCPHKKAVTLLPSFTMTPTA TESTASPTTSHRPTTTSHGN VTVHTSSGPTTVTHNPATTT SHGNATISHATVSPTTNGTA TSPRSSTVGPHPGPPPPSPS PRSKGALGNYTWANGSQPCV QLQAQIQIRILYPIQGGRKA WGISVLNPNKTKVQGGCDGT HPHLSLSFPYGQLTFGFKQD LHQSPSTVYLDYMAVEYNVS FPQAAQWTFMAQNSSLRELQ APLGQSFCCGNASIVLSPA |
| Tissue Specificity | Expressed in tissue macrophages and to a lesser extent in dendritic cells. |
| Post Translational Modifications | N- and O-glycosylated. |
| Function | Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. |
| Protein Name | MacrosialinCd Antigen Cd68 |
| Database Links | Reactome: R-MMU-6798695 |
| Cellular Localisation | Isoform Long: Endosome MembraneSingle-Pass Type I Membrane ProteinLysosome MembraneIsoform Short: Cell Membrane |
| Alternative Protein Names | Macrosialin proteinCd Antigen Cd68 proteinCd68 protein |
Information sourced from Uniprot.org
