| Tissue Specificity | High expression in thymus. Lower expression in lung and spleen. Expressed in both Th1 and Th2 cells. |
| Post Translational Modifications | |
| Function | Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity. Regulates IFN-gamma (IFNG)-mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
| Protein Name | Suppressor Of Cytokine Signaling 1Socs-1Jak-Binding ProteinJabStat-Induced Stat Inhibitor 1Ssi-1 |
| Database Links | Reactome: R-MMU-6785807Reactome: -MMU-877300Reactome: -MMU-877312Reactome: -MMU-909733Reactome: -MMU-9705462Reactome: -MMU-983168 |
| Cellular Localisation | NucleusCytoplasmic VesicleDetected In Perinuclear Cytoplasmic Vesicles Upon Interaction With Fgfr3 |
| Alternative ELISA Names | Suppressor Of Cytokine Signaling 1 ELISA kitSocs-1 ELISA kitJak-Binding Protein ELISA kitJab ELISA kitStat-Induced Stat Inhibitor 1 ELISA kitSsi-1 ELISA kitSocs1 ELISA kitCish1 ELISA kitSsi1 ELISA kit |
| output | |
Information sourced from Uniprot.org
