| Applications: | ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.14ng/mL |
| Detection Limit: | 0.312-20ng/mL |
| Short Description : | This SOCS1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse tissue homogenates, cell lysates or other biological fluids.. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | Socs1 |
| Gene ID: | 12703 |
| Uniprot ID: | SOCS1_MOUSE |
| Sample Type: | tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | High expression in thymus. Lower expression in lung and spleen. Expressed in both Th1 and Th2 cells. |
| Post Translational Modifications | |
| Function | Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity. Regulates IFN-gamma (IFNG)-mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
| Protein Name | Suppressor Of Cytokine Signaling 1 Socs-1 Jak-Binding Protein Jab Stat-Induced Stat Inhibitor 1 Ssi-1 |
| Database Links | Reactome: R-MMU-6785807 Reactome: -MMU-877300 Reactome: -MMU-877312 Reactome: -MMU-909733 Reactome: -MMU-9705462 Reactome: -MMU-983168 |
| Cellular Localisation | Nucleus Cytoplasmic Vesicle Detected In Perinuclear Cytoplasmic Vesicles Upon Interaction With Fgfr3 |
| Alternative ELISA Names | Suppressor Of Cytokine Signaling 1 ELISA kit Socs-1 ELISA kit Jak-Binding Protein ELISA kit Jab ELISA kit Stat-Induced Stat Inhibitor 1 ELISA kit Ssi-1 ELISA kit Socs1 ELISA kit Cish1 ELISA kit Ssi1 ELISA kit |
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Information sourced from Uniprot.org