| Tissue Specificity | Widely expressed. Isoform 1 and isoform 2 are expressed at higher level in brain and skeletal muscle. Isoform 7 is found in brain and spleen, isoform 10 is widely expressed but found at lower level in heart, kidney, liver and lung. |
| Post Translational Modifications | |
| Function | Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal. |
| Protein Name | Spermine OxidasePolyamine Oxidase 1Pao-1Paoh1 |
| Database Links | Reactome: R-MMU-141334Reactome: -MMU-351200 |
| Cellular Localisation | CytoplasmIsoform 2: CytoplasmNucleus |
| Alternative ELISA Names | Spermine Oxidase ELISA kitPolyamine Oxidase 1 ELISA kitPao-1 ELISA kitPaoh1 ELISA kitSmox ELISA kitSmo ELISA kit |
| output | |
Information sourced from Uniprot.org
