| Tissue Specificity | Highly expressed in cerebral cortex, brain, spinal cord, cerebellum and spleen, and at much lower levels in kidney, thymus, heart, lung and liver. Within the cerebellum, highly expressed throughout the molecular layer, and in synaptic glomeruli in the granule cell layer. Detected in neurons of the hippocampus and dentate gyrus, and in olfactory bulb. Not detected in Purkinje cells. Highly expressed in the plexiform layers, optic fiber layer and the outer segments of the photoreceptor layer in the retina. Highly expressed in macrophages. Isoform 3 is detected at very low levels in all tissues tested. |
| Post Translational Modifications | N-glycosylated. Phosphorylated on tyrosine residues. |
| Function | Immunoglobulin-like cell surface receptor for CD47. Acts as a docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization. Receptor for THBS1. Interaction with THBS1 stimulates phosphorylation of SIRPA. In response to THBS1, involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production. |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1Shp Substrate 1Shps-1Brain Ig-Like Molecule With Tyrosine-Based Activation MotifsBitCd172 Antigen-Like Family Member AInhibitory Receptor Shps-1Myd-1 AntigenSignal-Regulatory Protein Alpha-1Sirp-Alpha-1Msirp-Alpha1P84Cd Antigen Cd172a |
| Database Links | Reactome: R-MMU-202733Reactome: -MMU-391160Reactome: -MMU-6798695 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1 proteinShp Substrate 1 proteinShps-1 proteinBrain Ig-Like Molecule With Tyrosine-Based Activation Motifs proteinBit proteinCd172 Antigen-Like Family Member A proteinInhibitory Receptor Shps-1 proteinMyd-1 Antigen proteinSignal-Regulatory Protein Alpha-1 proteinSirp-Alpha-1 proteinMsirp-Alpha1 proteinP84 proteinCd Antigen Cd172a proteinSirpa proteinBit proteinMyd1 proteinPtpns1 proteinShps1 proteinSirp protein |
Information sourced from Uniprot.org
