Mouse SIRP-alpha/CD172a protein (Recombinant) (C-hFC) (STJP002827)

SKU:
STJP002827

£63.50 - £231.50
Current Stock:
Host: HEK293 cells
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse SIRP-alpha/CD172a-C-hFC protein was developed from hek293 cells and has a target region of C-hFC. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Measured by its binding ability in a functional ELISA.Immobilized Human CD47 (Catalog: RP01306) at 2 Mu g/mL (100 Mu L/well) can bind Mouse CD172a (Catalog: RP01619) with a linear range of 1.2-55.3 ng/mL.
Gene Symbol: Sirpa
Gene ID: 19261
Uniprot ID: SHPS1_MOUSE
Immunogen Region: Lys32-Asn373
Immunogen: Recombinant Mouse SIRP-alpha/CD172a Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys32-Asn373) of mouse SIRP-alpha/CD172a (Accession #NP_001277948.1) fused with a hFc tag at the C-terminus.
Post Translational Modifications N-glycosylated. Phosphorylated on tyrosine residues.
Function Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization. Receptor for THBS1. Interaction with THBS1 stimulates phosphorylation of SIRPA. In response to THBS1, involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production.
Protein Name Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1
Shp Substrate 1
Shps-1
Brain Ig-Like Molecule With Tyrosine-Based Activation Motifs
Bit
Cd172 Antigen-Like Family Member A
Inhibitory Receptor Shps-1
Myd-1 Antigen
Signal-Regulatory Protein Alpha-1
Sirp-Alpha-1
Msirp-Alpha1
P84
Cd Antigen Cd172a
Database Links Reactome: R-MMU-202733
Reactome: -MMU-2172127
Reactome: -MMU-391160
Reactome: -MMU-6798695
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1 protein
Shp Substrate 1 protein
Shps-1 protein
Brain Ig-Like Molecule With Tyrosine-Based Activation Motifs protein
Bit protein
Cd172 Antigen-Like Family Member A protein
Inhibitory Receptor Shps-1 protein
Myd-1 Antigen protein
Signal-Regulatory Protein Alpha-1 protein
Sirp-Alpha-1 protein
Msirp-Alpha1 protein
P84 protein
Cd Antigen Cd172a protein
Sirpa protein
Bit protein
Myd1 protein
Ptpns1 protein
Shps1 protein
Sirp protein

Information sourced from Uniprot.org

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