Mouse SIGLEC12 protein (Recombinant) (N-His) (STJP011351)

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STJP011351
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse SIGLEC12-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: Siglec12
Gene ID: 83382
Uniprot ID: SIG12_MOUSE
Immunogen Region: Gln19-Ala253
Immunogen: Mus musculus (Mouse)
Post Translational Modifications Phosphorylation of Tyr-432 is required for binding to PTPN6 and PTPN11. Phosphorylation of Tyr-455 is involved in binding to PTPN6. Tyr-432 needs to be phosphorylated prior to Tyr-455.
Function Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
Protein Name Sialic Acid-Binding Ig-Like Lectin 12
Siglec-12
Myeloid Inhibitory Siglec
Mis
Sialic Acid-Binding Ig-Like Lectin 5
Siglec-5
Sialic Acid-Binding Ig-Like Lectin E
Siglec-E
Msiglec-E
Sialic Acid-Binding Ig-Like Lectin-Like 1
Siglec-L1
Database Links Reactome: R-MMU-198933
Reactome: -MMU-6798695
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Sialic Acid-Binding Ig-Like Lectin 12 protein
Siglec-12 protein
Myeloid Inhibitory Siglec protein
Mis protein
Sialic Acid-Binding Ig-Like Lectin 5 protein
Siglec-5 protein
Sialic Acid-Binding Ig-Like Lectin E protein
Siglec-E protein
Msiglec-E protein
Sialic Acid-Binding Ig-Like Lectin-Like 1 protein
Siglec-L1 protein
Siglec12 protein
Siglec5 protein
Siglece protein
Siglecl1 protein

Information sourced from Uniprot.org