| Post Translational Modifications | Phosphorylation of Tyr-432 is required for binding to PTPN6 and PTPN11. Phosphorylation of Tyr-455 is involved in binding to PTPN6. Tyr-432 needs to be phosphorylated prior to Tyr-455. |
| Function | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. |
| Protein Name | Sialic Acid-Binding Ig-Like Lectin 12Siglec-12Myeloid Inhibitory SiglecMisSialic Acid-Binding Ig-Like Lectin 5Siglec-5Sialic Acid-Binding Ig-Like Lectin ESiglec-EMsiglec-ESialic Acid-Binding Ig-Like Lectin-Like 1Siglec-L1 |
| Database Links | Reactome: R-MMU-198933Reactome: -MMU-6798695 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Sialic Acid-Binding Ig-Like Lectin 12 proteinSiglec-12 proteinMyeloid Inhibitory Siglec proteinMis proteinSialic Acid-Binding Ig-Like Lectin 5 proteinSiglec-5 proteinSialic Acid-Binding Ig-Like Lectin E proteinSiglec-E proteinMsiglec-E proteinSialic Acid-Binding Ig-Like Lectin-Like 1 proteinSiglec-L1 proteinSiglec12 proteinSiglec5 proteinSiglece proteinSiglecl1 protein |
Information sourced from Uniprot.org
