| Applications: | ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.055ng/mL |
| Detection Limit: | 0.156-10ng/mL |
| Short Description : | This SGPL1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse tissue homogenates or other biological fluids.. |
| Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
| Gene Symbol: | Sgpl1 |
| Gene ID: | 20397 |
| Uniprot ID: | SGPL1_MOUSE |
| Immunogen Region: | Ready-To-Use |
| Sample Type: | tissue homogenates or other biological fluids. |
| Tissue Specificity | Highest levels are found in liver, small intestine and thymus, followed by kidney, lung, heart, spleen and brain (at protein level). Also detected in stomach, testis and skeletal muscle (at protein level). |
| Post Translational Modifications | |
| Function | Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP. Seems to play a role in establishing neuronal contact sites and axonal maintenance. |
| Protein Name | Sphingosine-1-Phosphate Lyase 1 S1pl Sp-Lyase 1 Spl 1 Mspl Sphingosine-1-Phosphate Aldolase |
| Database Links | Reactome: R-MMU-9845614 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Single-Pass Type Iii Membrane Protein Cytoplasmic Side |
| Alternative ELISA Names | Sphingosine-1-Phosphate Lyase 1 ELISA kit S1pl ELISA kit Sp-Lyase 1 ELISA kit Spl 1 ELISA kit Mspl ELISA kit Sphingosine-1-Phosphate Aldolase ELISA kit Sgpl1 ELISA kit Spl ELISA kit |
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Information sourced from Uniprot.org