Mouse SEMA4A protein (Recombinant) (C-His) (STJP014059)

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STJP014059-100
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Short Description :Recombinant-Mouse SEMA4A-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Applications:ELISA/WB
Host:Mammalian Cells
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Dilution Range:Reconstitute in sterile water for a stock solution.
Formulation:Lyophilized from a 0.22 Mu m filtered solution in 20mM PB, 150mM NaCl, 1mM EDTA, 5% Trehalose, pH 7.4.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:< 1 EU/µg as determined by LAL test.
Gene Symbol:Sema4a
Gene ID:20351
Uniprot ID:SEM4A_MOUSE
Immunogen:Mus musculus (Mouse)
Immunogen Region:Thr33-His682
Function Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Regulates glutamatergic and GABAergic synapse development. Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
Protein Name Semaphorin-4a
Semaphorin-B
Sema B
Database Links Reactome: R-MMU-416700
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Semaphorin-4a protein
Semaphorin-B protein
Sema B protein
Sema4a protein
Semab protein
SemB protein

Information sourced from Uniprot.org

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