| Tissue Specificity | Detected in neurons in the thalamus. Detected in embryonic vasculature. Developing lungs, developing skeletal elements and ventral horns of the developing neural tube. Correlates positively with tumor progression. |
| Post Translational Modifications | |
| Function | Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation. |
| Protein Name | Semaphorin-3eSemaphorin-HSema H |
| Database Links | Reactome: R-MMU-416700 |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | Semaphorin-3e ELISA kitSemaphorin-H ELISA kitSema H ELISA kitSema3e ELISA kitSemah ELISA kitSemh ELISA kit |
| output | |
Information sourced from Uniprot.org
