Mouse RUNX2 protein (Recombinant) (N-His) (STJP014886)

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STJP014886-100
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Host: E.coli
Applications: ELISA/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse RUNX2-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: Please contact us for this information.
Gene Symbol: Runx2
Gene ID: 12393
Uniprot ID: RUNX2_MOUSE
Immunogen Region: Pro422-Arg554
Immunogen: Mus musculus (Mouse)
Post Translational Modifications Phosphorylated.probably by MAP kinases (MAPK). Phosphorylation by HIPK3 is required for the SPEN/MINT and FGF2 transactivation during osteoblastic differentiation. Phosphorylation at Ser-537 by CDK1 promotes endothelial cell proliferation required for tumor angiogenesis probably by facilitating cell cycle progression.
Function Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).
Protein Name Runt-Related Transcription Factor 2
Acute Myeloid Leukemia 3 Protein
Core-Binding Factor Subunit Alpha-1
Cbf-Alpha-1
Oncogene Aml-3
Osteoblast-Specific Transcription Factor 2
Osf-2
Polyomavirus Enhancer-Binding Protein 2 Alpha A Subunit
Pea2-Alpha A
Pebp2-Alpha A
Sl3-3 Enhancer Factor 1 Alpha A Subunit
Sl3/Akv Core-Binding Factor Alpha A Subunit
Database Links Reactome: R-MMU-8878166 Q08775-5
Reactome: -MMU-8939902 Q08775-5
Reactome: -MMU-8940973 Q08775-5
Reactome: -MMU-8941326 Q08775-5
Cellular Localisation Nucleus
Cytoplasm
Alternative Protein Names Runt-Related Transcription Factor 2 protein
Acute Myeloid Leukemia 3 Protein protein
Core-Binding Factor Subunit Alpha-1 protein
Cbf-Alpha-1 protein
Oncogene Aml-3 protein
Osteoblast-Specific Transcription Factor 2 protein
Osf-2 protein
Polyomavirus Enhancer-Binding Protein 2 Alpha A Subunit protein
Pea2-Alpha A protein
Pebp2-Alpha A protein
Sl3-3 Enhancer Factor 1 Alpha A Subunit protein
Sl3/Akv Core-Binding Factor Alpha A Subunit protein
Runx2 protein
Aml3 protein
Cbfa1 protein
Osf2 protein
Pebp2a protein

Information sourced from Uniprot.org

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