| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
27pg/mL |
| Detection Limit: |
78.1-5000pg/mL |
| Short Description: |
This PF4 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse serum, platelet-poor plasma, cell culture supernates or other biological fluids.. |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
3 hrs |
| Gene Symbol: |
Pf4 |
| Gene ID: |
56744 |
| Uniprot ID: |
PLF4_MOUSE |
| Immunogen Region: |
Ready-To-Use |
| Sample Type: |
serum, platelet-poor plasma, cell culture supernates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Chemokine released during platelet aggregation that plays a role in different biological processes including hematopoiesis, cell proliferation, differentiation, and activation. Acts via different functional receptors including CCR1, CXCR3A or CXCR3B. Upon interaction with CXCR3A receptor, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling. Neutralizes the anticoagulant effect of heparin by binding more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Plays a role in the inhibition of hematopoiesis and in the maintenance of hematopoietic stem cell (HSC) quiescence. Chemotactic for neutrophils and monocytes via CCR1. Inhibits endothelial cell proliferation. In cooperation with toll-like receptor 8/TLR8, induces chromatin remodeling and activates inflammatory gene expression via the TBK1-IRF5 axis. In addition, induces myofibroblast differentiation and collagen synthesis in different precursor cells, including endothelial cells, by stimulating endothelial-to-mesenchymal transition. Interacts with thrombomodulin/THBD to enhance the activation of protein C and thus potentiates its anticoagulant activity. |
| Protein Name | Platelet Factor 4Pf-4C-X-C Motif Chemokine 4 |
| Database Links | Reactome: R-MMU-114608Reactome: -MMU-140875Reactome: -MMU-202733Reactome: -MMU-380108Reactome: -MMU-418594 |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | Platelet Factor 4 ELISA kitPf-4 ELISA kitC-X-C Motif Chemokine 4 ELISA kitPf4 ELISA kitCxcl4 ELISA kitScyb4 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
