| Applications: | ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.124ng/mL |
| Detection Limit: | 0.312-20ng/mL |
| Short Description : | This PAX6 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse tissue homogenates or other biological fluids.. |
| Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
| Gene Symbol: | Pax6 |
| Gene ID: | 18508 |
| Uniprot ID: | PAX6_MOUSE |
| Immunogen Region: | Ready-To-Use |
| Sample Type: | tissue homogenates or other biological fluids. |
| Tissue Specificity | Expressed in osteoclasts. Isoform 1: Dominant isoform expressed in the eye, including in the retina and cornea. Abundantly expressed in the lens epithelium. Isoform 3: Dominant isoform expressed in the eye, including in the retina and cornea. Weakly expressed in the lens epithelium. |
| Post Translational Modifications | Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation. Isoform 3: Sumoylated by SUMO1 at 'Lys-91'. |
| Function | Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains. Acts as a transcriptional repressor of NFATC1-mediated gene expression. |
| Protein Name | Paired Box Protein Pax-6 Oculorhombin |
| Database Links | |
| Cellular Localisation | Nucleus Isoform 1: Nucleus Isoform 3: Nucleus Cytoplasm Isoform 5a: Nucleus |
| Alternative ELISA Names | Paired Box Protein Pax-6 ELISA kit Oculorhombin ELISA kit Pax6 ELISA kit Pax-6 ELISA kit Sey ELISA kit |
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Information sourced from Uniprot.org