| Tissue Specificity | Expressed in osteoclasts. Isoform 1: Dominant isoform expressed in the eye, including in the retina and cornea. Abundantly expressed in the lens epithelium. Isoform 3: Dominant isoform expressed in the eye, including in the retina and cornea. Weakly expressed in the lens epithelium. |
| Post Translational Modifications | Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation. Isoform 3: Sumoylated by SUMO1 at 'Lys-91'. |
| Function | Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains. Acts as a transcriptional repressor of NFATC1-mediated gene expression. |
| Protein Name | Paired Box Protein Pax-6Oculorhombin |
| Database Links | |
| Cellular Localisation | NucleusIsoform 1: NucleusIsoform 3: NucleusCytoplasmIsoform 5a: Nucleus |
| Alternative ELISA Names | Paired Box Protein Pax-6 ELISA kitOculorhombin ELISA kitPax6 ELISA kitPax-6 ELISA kitSey ELISA kit |
| output | |
Information sourced from Uniprot.org
