| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.1 EU/Mu g |
| Gene Symbol: | Pth |
| Gene ID: | 19226 |
| Uniprot ID: | PTHY_MOUSE |
| Immunogen Region: | Lys26-Gln115 |
| Immunogen: | Recombinant Mouse Parathormone/PTH Protein is produced by E. coli expression system. The target protein is expressed with sequence (Lys26-Gln115) of mouse Parathormone/PTH (Accession #NM_020623.2) fused with no additional amino acid. |
| Immunogen Sequence: | MPSQMEHAMETMMFTFHKFA GDKGYLTKEDLRVLMEKEFP GFLENQKDPLAVDKIMKDLD QCRDGKVGFQSFFSLIAGLT IACNDYFVVHMKQKGKK |
| Tissue Specificity | Highly expressed in the parathyroid gland. Also expressed in the placenta, thymus and testis. |
| Function | Parathyroid hormone elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Acts by binding to its receptor, PTH1R, activating G protein-coupled receptor signaling. Stimulates 1-14C-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. |
| Protein Name | Parathyroid HormonePth |
| Database Links | Reactome: R-MMU-373080Reactome: -MMU-418555 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Parathyroid Hormone proteinPth proteinPth protein |
Information sourced from Uniprot.org
