Tissue Specificity | Osteoblast/chondrocyte specific. |
Post Translational Modifications | Propionylated. Depropionylation at Lys-368 by SIRT7 activates transcription factor activity and positively regulates bone formation by osteoblasts. Ubiquitination at leads to proteasomal degradation. SP7 is a short-live protein with an endogenous half-life of approximately 12 hours. |
Function | Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences. |
Protein Name | Transcription Factor Sp7C22Zinc Finger Protein Osterix |
Database Links | |
Cellular Localisation | Nucleus |
Alternative ELISA Names | Transcription Factor Sp7 ELISA kitC22 ELISA kitZinc Finger Protein Osterix ELISA kitSp7 ELISA kitOsx ELISA kit |
output | |
Information sourced from Uniprot.org